Nicholas G. Theodorakis, Ph.D. Molecular Biologist

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Research Papers

  1. Theodorakis NG, Wang YN, Wu JM, Maluccio MA, Skill NJ. (2010) Tumor necrosis factor-alpha signaling in the development of experimental murine pre-hepatic portal hypertension. International Journal of Physiology, Pathophysiology and Pharmacology. [In Press]
  2. Theodorakis NG, Wang YN, Wu JM, Maluccio MA, Sitzmann JV, Skill NJ. (2009) Role of endothelial nitric oxide synthase in the development of portal hypertension in the carbon tetrachloride induced liver fibrosis model. Am J Physiol Gastrointest Liver Physiol. [Epub ahead of print] PMID: 19628654
  3. Skill NJ, Theodorakis NG, Wang YN, Wu JM, Redmond EM, Sitzmann JV. (2008) Role of cyclooxygenase isoforms in prostacyclin biosynthesis and murine prehepatic portal hypertension. Am J Physiol Gastrointest Liver Physiol. 295(5): G953-64. PMID: 18772366
  4. Kovach SJ, Price JA, Theodorakis NG, McKillop IH. (2006) Role of cyclic-AMP responsive element binding (CREB) proteins in cell proliferation in a rat model of hepatocellular carcinoma. J Cell Physiol. 206(2):411-9. PMID: 16110470
  5. Cullen JP, Sayeed S, Kim Y, Theodorakis NG, Sitzmann JV, Cahill PA, Redmond EM. (2005) Ethanol inhibits pulse pressure-induced vascular smooth muscle cell migration by differentially modulating plasminogen activator inhibitor type 1, matrix metalloproteinase-2 and -9. Thromb Haemost. 94(3):639-45. PMID: 16268483
  6. Cullen JP, Sayeed S, Jin Y, Theodorakis NG, Sitzmann JV, Cahill PA, Redmond EM. (2005) Ethanol inhibits monocyte chemotactic protein-1 expression in interleukin-1β-activated human endothelial cells. Am J Physiol Heart Circ Physiol. 289(4):H1669-75. PMID :15908470
  7. Theodorakis NG, Wang YN, Skill NJ, Metz MA, Cahill PA, Redmond EM, Sitzmann JV. (2003) The role of nitric oxide synthase isoforms in extrahepatic portal hypertension: studies in gene-knockout mice. Gastroenterology. 124(5):1500-8. PMID: 12730888
  8. Cullen JP, Sayeed S, Sawai RS, Theodorakis NG, Cahill PA, Sitzmann JV, Redmond EM. (2002) Pulsatile flow-induced angiogenesis: role of G(i) subunits. Arterioscler Thromb Vasc Biol. 22(10):1610-6. PMID: 12377738
  9. Paidas CN, Mooney ML, Theodorakis NG, De Maio A. (2002) Accelerated recovery after endotoxic challenge in heat shock-pretreated mice. Am J Physiol Regul Integr Comp Physiol. 282(5): R1374-81. PMID: 11959679
  10. Gingalewski C, Theodorakis NG, Clemens MG, De Maio A. (2000) Interruption of hepatic gap junctional communication in the rat during inflammation induced by bacterial lipopolysaccharide. Shock 14(1): 53-9. PMID: 10909894
  11. Cappadona C, Redmond EM, Theodorakis NG, McKillop IH, Hendrickson R, Chhabra A, Sitzmann JV, Cahill PA. (1999) Phenotype dictates the growth response of vascular smooth muscle cells to pulse pressure in vitro. Exp Cell Res. 250(1): 174-86. PMID: 10388531
  12. Theodorakis NG, De Maio, A. (1999). Cx32 mRNA in rat liver: effects of inflammation and inhibition of transcription or translation on poly(A) tail distribution and mRNA degradation. Am J Physiol. 276(5 Pt 2): R1249-57. PMID: 10233014
  13. Theodorakis NG, Drujan D, De Maio A. (1999) Thermotolerant cells show an attenuated expression of Hsp70 after heat shock. J. Biol. Chem. 274(17): 12081-6. PMID: 10207033
  14. Gingalewski C, Theodorakis NG, Yang J, Beck, SC, De Maio A. (1996) Distinct expression of heat shock and acute phase genes during regional hepatic ischemia-reperfusion. Am J Physiol. 271(3 Pt 2): R634-40. PMID: 8853385
  15. Bachurski CJ, Theodorakis NG, Coulson RMC, Cleveland DW. (1994) An amino-terminal peptide specifies degradation of alpha- tubulin, but not beta-tubulin, mRNAs. Mol Cell Biol. 14(6): 4076-86. PMID: 8196646
  16. Katz DA, Theodorakis NG, Cleveland DW, Lindsten T, Thompson CB. (1994) AU-A, an RNA-binding activity distinct from hnRNP A1, is selective for AUUUA repeats and shuttles between the nucleus and the cytoplasm. Nucleic Acids Res. 22(2): 238-46. PMID: 8121809
  17. Theodorakis NG, Cleveland DW. (1992). Physical evidence for cotranslational regulation of beta-tubulin mRNA degradation. Mol Cell Biol. 12(2): 791-9. PMID: 1732744
  18. Theodorakis NG, Zand DJ, Kotzbauer PT, Williams GT, Morimoto RI. (1989) Hemin-induced transcriptional activation of the HSP70 gene during erythroid maturation in K562 cells is due to a heat shock factor-mediated stress response. Mol Cell Biol. 9(8): 3166-73. PMID: 2796986
  19. Mosser DD, Theodorakis NG, Morimoto RI. (1988) Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells. Mol Cell Biol. 8(11): 4736-44. PMID: 3211126
  20. Theodorakis NG, Banerji SS, Morimoto RI. (1988) HSP70 mRNA translation in chicken reticulocytes is regulated at the level of elongation. J Biol Chem. 263(28): 14579-85. PMID: 3170555
  21. Shaefer EL, Morimoto RI, Theodorakis NG, Seidenfeld, J. (1988) Chemical specificity for induction of stress response genes by DNA-damaging drugs in human adenocarcinoma cells. Carcinogenesis 9(10): 1733-8. PMID: 3168151
  22. Theodorakis NG, Morimoto, RI. (1987) Posttranscriptional regulation of hsp70 expression in human cells: effects of heat shock, inhibition of protein synthesis, and adenovirus infection on translation and mRNA stability. Mol Cell Biol. 7(12): 4357-68. PMID: 3437893
  23. Banerji SS, Theodorakis NG, Morimoto RI. (1984) Heat shock-induced translational control of HSP70 and globin synthesis in chicken reticulocytes. Mol Cell Biol. 4(11): 2437-48. PMID: 6513924
  24. Kost TA, Theodorakis N, Hughes SH. (1983) The nucleotide sequence of the chick cytoplasmic beta-actin gene. Nucleic Acids Res. 11(23): 8287-301. PMID: 6324080

Book Chapters

  1. Theodorakis, NG, Cleveland DW. (1996) “Translationally-coupled degradation of mRNA in eukaryotes.” in Translational Control (Hershey, Mathews and Sonenberg, eds.) Cold Spring Harbor Press, NY. pp. 631-652.
  2. Cleveland DW, Theodorakis NG. (1994) “Regulation of tubulin synthesis.” in Microtubules (Hyams and Lloyd eds.) Wiley-Liss, NY. pp. 47-58.
  3. Theodorakis NG, Cleveland DW. (1993) “Translationally Coupled Degradation of Tubulin mRNA.” in Control of mRNA Stability (Belasco and Brawerman, eds.) Academic Press, Inc. San Diego. pp. 219-238.
  4. Morimoto RI, Mosser D, McClanahan TK, Theodorakis NG, Williams G. (1989) “Transcriptional regulation of the human HSP70 gene.” in Stress-Induced Proteins (Pardue, Feramisco, and Lindquist, eds.) A.R. Liss, Inc., NY. pp. 83-94.

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